No Consistent Bioenergetic Defects in Presynaptic Nerve Terminals Isolated from Mouse Models of Alzheimer's Disease
نویسندگان
چکیده
منابع مشابه
Neurobiology of Disease No Consistent Bioenergetic Defects in Presynaptic Nerve Terminals Isolated from Mouse Models of Alzheimer’s Disease
Depressed cortical energy supply and impaired synaptic function are predominant associations of Alzheimer’s disease (AD). To test the hypothesis that presynaptic bioenergetic deficits are associated with the progression of AD pathogenesis, we compared bioenergetic variables of cortical and hippocampal presynaptic nerve terminals (synaptosomes) from commonly used mouse models with AD-like phenot...
متن کاملThe Regulation of Cytosolic pH in Isolated Presynaptic Nerve Terminals from Rat Brain
I N T R O D U C T I O N Cytosolic p H (pHi) is a key regu la to r o f many cellular processes (e.g., Roos and Boron, 1981), including the release o f neuro t ransmi t te r s f rom presynaptic nerve * Deceased December 16, 1986. Address reprint requests to Dr. Pierre Drapeau, Neurology Dept., Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada. J. GF~. PHYSIOL. 9 The Rockefeller Universi...
متن کاملThe regulation of cytosolic pH in isolated presynaptic nerve terminals from rat brain
Cytosolic pH (pHi) was measured in presynaptic nerve terminals isolated from rat brain (synaptosomes) using a fluorescent pH indicator, 2',7'-bis(carboxyethyl)-5,6-carboxyfluorescein (BCECF). The synaptosomes were loaded with BCECF by incubation with the membrane-permanent acetoxy-methyl ester derivative of BCECF, which is hydrolyzed by intracellular esterases to the parent compound. pHi was es...
متن کاملLocalization of Calcium in Presynaptic Nerve Terminals
Ultrastructural techniques and electron probe microanalysis were used to determine whether or not the smooth endoplasmic reticulum (SER) within presynaptic nerve terminals is a Ca-sequestering site . The three-dimensional structure of the SER was determined from serial sections of synaptosomes. The SER consists of flattened cisterns that may branch and are frequently juxtaposed to mitochondria ...
متن کاملThe Regulation of Cytosolic pH in Isolated Presynaptic Nerve Terminals from Rat Brain
I N T R O D U C T I O N Cytosolic p H (pHi) is a key regu la to r o f many cellular processes (e.g., Roos and Boron, 1981), including the release o f neuro t ransmi t te r s f rom presynaptic nerve * Deceased December 16, 1986. Address reprint requests to Dr. Pierre Drapeau, Neurology Dept., Montreal General Hospital, Montreal, Quebec H3G 1A4, Canada. J. GF~. PHYSIOL. 9 The Rockefeller Universi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.2414-12.2012